Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus
نویسندگان
چکیده
منابع مشابه
Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus.
OBJECTIVES To establish whether surgery can improve the neuropsychological functioning of young adult patients with spina bifida and apparent clinically arrested hydrocephalus showing abnormal intracranial pressure. METHODS Twenty three young adults with spina bifida and assumed arrested hydrocephalus (diagnosed as active or compensated by continuous intracranial pressure monitoring) underwen...
متن کاملImpact of Cerebrospinal Fluid Shunting for Idiopathic Normal Pressure Hydrocephalus on the Amyloid Cascade
The aim of this study was to determine whether the improvement of cerebrospinal fluid (CSF) flow dynamics by CSF shunting, can suppress the oligomerization of amyloid β-peptide (Aβ), by measuring the levels of Alzheimer's disease (AD)-related proteins in the CSF before and after lumboperitoneal shunting. Lumbar CSF from 32 patients with idiopathic normal pressure hydrocephalus (iNPH) (samples w...
متن کاملGross enophthalmos after cerebrospinal fluid shunting for childhood hydrocephalus: the "silent brain syndrome".
PURPOSE To describe the clinical characteristics and ophthalmic management of 2 patients who developed gross enophthalmos after ventriculo-peritoneal shunting performed in their teenage years. A key radiologic feature is presented, and a conjectural mechanism is proposed for this disfiguring condition. METHODS Retrospective case note review for 2 patients requiring ophthalmic care for gross e...
متن کاملCerebrospinal fluid biomarkers of infantile congenital hydrocephalus
INTRODUCTION Hydrocephalus is a complex neurological disorder with a pervasive impact on the central nervous system. Previous work has demonstrated derangements in the biochemical profile of cerebrospinal fluid (CSF) in hydrocephalus, particularly in infants and children, in whom neurodevelopment is progressing in parallel with concomitant neurological injury. The objective of this study was to...
متن کاملDETECTION OF CRYPTOCOCCUS NEOFORMANS BY SEMINESTED PCR IN CEREBROSPINAL FLUID
ABSTRACT Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years. Cryptococcus neoformans is recognized as the most frequent fungal infection of the central nervous system (CNS) in immunocompetent as well as immunocompromised patients. We report the development of a semi-nested- PCR-based assay for the ...
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ژورنال
عنوان ژورنال: Cerebrospinal Fluid Research
سال: 2007
ISSN: 1743-8454
DOI: 10.1186/1743-8454-4-5